Sequence Detail

ID/Version

O54990 Q80XB6 Q80XB2 O35408 O54990 Q8BH12 (UniProt | EBI)

Last sequence update: 1998-06-01 Last annotation update: 2012-11-28

Sequence description from provider

RecName: Full=Prominin-1;AltName: Full=Antigen AC133 homolog;AltName: Full=Prominin-like protein 1;AltName: CD_antigen=CD133;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 867 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prom1	prominin 1	28	10	5	5

Sequence references in MGI

J:44182 Weigmann A, et al., Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12425-30
J:77557 Fargeas CA, et al., Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. J Biol Chem. 2003 Mar 7;278(10):8586-96
J:92183 Fargeas CA, et al., Identification of novel Prominin-1/CD133 splice variants with alternative C-termini and their expression in epididymis and testis. J Cell Sci. 2004 Aug 15;117(Pt 18):4301-11
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140984 Yang Z, et al., Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 2008 Aug;118(8):2908-16
J:146585 Zacchigna S, et al., Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci. 2009 Feb 18;29(7):2297-308
J:168197 Dubreuil V, et al., Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol. 2007 Feb 12;176(4):483-95
J:168820 Florek M, et al., Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine. Cell Tissue Res. 2007 Apr;328(1):31-47