Sequence Detail

ID/Version

O54982 D3Z5P2 G3X9P7 (UniProt | EBI)

Last sequence update: 2024-07-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Potassium channel subfamily U member 1;AltName: Full=Calcium-activated potassium channel subunit alpha-3;AltName: Full=Calcium-activated potassium channel, subfamily M subunit alpha-3;AltName: Full=Pore-forming subunit of the sperm-specific

Provider

SWISS-PROT

Sequence

Polypeptide 1121 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnu1	potassium channel, subfamily U, member 1	38	97	2	13

Sequence references in MGI

J:45626 Schreiber M, et al., Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem. 1998 Feb 6;273(6):3509-16
J:157522 Santi CM, et al., The SLO3 sperm-specific potassium channel plays a vital role in male fertility. FEBS Lett. 2010 Mar 5;584(5):1041-6
J:171225 Zeng XH, et al., Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5879-84
J:180391 Yang C, et al., LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19419-24
J:192262 Leonetti MD, et al., Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19274-9
J:220171 Zeng XH, et al., SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2599-604