Sequence Detail

ID/Version

O54957 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Linker for activation of T-cells family member 1;AltName: Full=36 kDa phosphotyrosine adapter protein; Short=pp36;AltName: Full=p36-38;

Provider

SWISS-PROT

Sequence

Polypeptide 242 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lat	linker for activation of T cells	49	97	3	22

Sequence references in MGI

J:54183 Zhang W, et al., LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 1998 Jan 9;92(1):83-92
J:111435 Saitoh S, et al., LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity. 2000 May;12(5):525-35
J:151596 Hundt M, et al., Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. J Immunol. 2009 Aug 1;183(3):1685-94
J:186446 Wang D, et al., Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012 Jun;13(6):560-8
J:189787 Lesourne R, et al., Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol. 2012 Aug 1;189(3):1154-61
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89