Sequence Detail

ID/Version

O54949 Q6PF98 Q5SYE6 (UniProt | EBI)

Last sequence update: 2009-11-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase NLK; EC=2.7.11.24 {ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:17785444};AltName: Full=Nemo-like kinase;

Provider

SWISS-PROT

Sequence

Polypeptide 527 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlk	nemo like kinase	58	106	4	77

Sequence references in MGI

J:45651 Brott BK, et al., Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):963-8
J:73353 Kortenjann M, et al., Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk. Eur J Immunol. 2001 Dec;31(12):3580-7
J:89440 Kanei-Ishii C, et al., Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004 Apr 1;18(7):816-29
J:148054 Satoh K, et al., Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. Mol Cell Biol. 2007 Nov;27(21):7623-30
J:148070 Ohkawara B, et al., Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 2004 Feb 15;18(4):381-6
J:150924 Yasuda J, et al., Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB. Cancer Sci. 2004 Jan;95(1):52-7
J:163054 Li M, et al., TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J Biol Chem. 2010 Apr 30;285(18):13397-404
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89