Sequence Detail

ID/Version

O54864 Q3UT51 Q9JLC7 Q8C2L3 Q9JLP8 Q3TEW2 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase SUV39H1; EC=2.1.1.355 {ECO:0000269|PubMed:10949293};AltName: Full=Histone H3-K9 methyltransferase 1; Short=H3-K9-HMTase 1;AltName: Full=Position-effect variegation 3-9 homolog;AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 412 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Suv39h1	suppressor of variegation 3-9 1	106	116	4	18

Sequence references in MGI

J:54310 Aagaard L, et al., Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 1999 Apr 1;18(7):1923-38
J:61103 Bultman S, et al., Molecular and genetic analysis of the mouse homolog of the Drosophila suppressor of position-effect variegation 3-9 gene. Mamm Genome. 2000 Apr;11(4):251-4
J:65972 O'Carroll D, et al., Isolation and characterization of suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol Cell Biol. 2000 Dec;20(24):9423-33
J:72503 Peters AH, et al., Loss of the suv39h histone methyltransferases impairs Mammalian heterochromatin and genome stability. Cell. 2001 Nov 2;107(3):323-37
J:75203 Rea S, et al., Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature. 2000 Aug 10;406(6796):593-9
J:88268 Garcia-Cao M, et al., Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet. 2004 Jan;36(1):94-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114014 Vaute O, et al., Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res. 2002 Jan 15;30(2):475-81
J:127714 Vaquero A, et al., SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature. 2007 Nov 15;450(7168):440-4
J:138307 Spensberger D, et al., A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS Lett. 2008 Aug 6;582(18):2761-7
J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32
J:244335 Liu B, et al., Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun. 2013;4:1868
J:266543 Zhang YL, et al., DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89