Sequence Detail

ID/Version

O54754 Q9Z2Z5 Q9WU85 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Aldehyde oxidase 1 {ECO:0000312|MGI:MGI:88035}; EC=1.2.3.1 {ECO:0000269|PubMed:10190983, ECO:0000269|PubMed:19401776};AltName: Full=Azaheterocycle hydroxylase 1; EC=1.17.3.-;AltName: Full=Retinal oxidase {ECO:0000303|PubMed:1

Provider

SWISS-PROT

Sequence

Polypeptide 1333 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aox1	aldehyde oxidase 1	40	98	4	8

Sequence references in MGI

J:42233 Bendotti C, et al., Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons. Neuroreport. 1997 Jul 7;8(9-10):2343-9
J:54214 Huang DY, et al., Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Arch Biochem Biophys. 1999 Apr 15;364(2):264-72
J:56506 Kurosaki M, et al., Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. Biochem J. 1999 Jul 1;341(Pt 1):71-80
J:59200 Demontis S, et al., The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region. Biochim Biophys Acta. 1999 Dec 23;1489(2-3):207-22
J:140048 Weigert J, et al., Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release. FEBS Lett. 2008 Aug 20;582(19):2965-72
J:148259 Schumann S, et al., Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1. PLoS One. 2009;4(4):e5348
J:206899 Swenson TL, et al., Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice. Toxicol Sci. 2013 May;133(1):22-8
J:228048 Kurosaki M, et al., Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Cell Mol Life Sci. 2013 May;70(10):1807-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89