Sequence Detail

ID/Version

O54714 Q80WF8 Q8R598 (UniProt | EBI)

Last sequence update: 2004-12-07
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 SUMO-protein ligase PIAS3; EC=2.3.2.-;AltName: Full=E3 SUMO-protein transferase PIAS3 {ECO:0000305};AltName: Full=Protein inhibitor of activated STAT protein 3;

Provider

SWISS-PROT

Sequence

Polypeptide 628 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pias3	protein inhibitor of activated STAT 3	53	108	2	18

Sequence references in MGI

J:52872 Chung CD, et al., Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5
J:63546 Sturm S, et al., Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons. J Mol Neurosci. 2000 Feb-Apr;14(1-2):107-21
J:82166 Jimenez-Lara AM, et al., PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2. FEBS Lett. 2002 Aug 28;526(1-3):142-6
J:86405 Duval D, et al., The 'PINIT' motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L. FEBS Lett. 2003 Nov 6;554(1-2):111-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:142156 Kuwata T, et al., BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body. Genes Cells. 2008 Sep;13(9):931-40
J:175118 Rodel B, et al., The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J. 2000 Nov 1;19(21):5845-55