Sequence Detail

ID/Version

O54689 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=C-C chemokine receptor type 6; Short=C-C CKR-6; Short=CC-CKR-6; Short=CCR-6;AltName: Full=KY411;AltName: CD_antigen=CD196;

Provider

SWISS-PROT

Sequence

Polypeptide 367 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ccr6	C-C motif chemokine receptor 6	49	101	4	13

Sequence references in MGI

J:51311 Varona R, et al., Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha. FEBS Lett. 1998 Nov 27;440(1-2):188-94
J:142071 Yamazaki T, et al., CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol. 2008 Dec 15;181(12):8391-401
J:191919 Wang C, et al., The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009 Mar;2(2):173-83
J:233563 Bunting MD, et al., CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development. Immunol Cell Biol. 2014 Jul;92(6):489-98
J:233566 Caballero-Campo P, et al., A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. J Cell Physiol. 2014 Jan;229(1):68-78
J:233575 Rohrl J, et al., Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells. J Biol Chem. 2010 Mar 5;285(10):7028-34
J:233674 Reboldi A, et al., IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13;352(6287):aaf4822
J:244347 Elgueta R, et al., CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen. J Immunol. 2015 Jan 15;194(2):505-13