Sequence Detail

ID/Version

O35973 B1ASX0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Period circadian protein homolog 1; Short=mPER1;AltName: Full=Circadian clock protein PERIOD 1;AltName: Full=Circadian pacemaker protein Rigui;

Provider

SWISS-PROT

Sequence

Polypeptide 1291 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Per1	period circadian clock 1	78	135	4	24

Sequence references in MGI

J:43060 Sun ZS, et al., RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell. 1997 Sep 19;90(6):1003-11
J:43293 Tei H, et al., Circadian oscillation of a mammalian homologue of the Drosophila period gene [see comments]. Nature. 1997 Oct 2;389(6650):512-6
J:45182 Shearman LP, et al., Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec;19(6):1261-9
J:51392 Sangoram AM, et al., Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998 Nov;21(5):1101-13
J:57184 Takumi T, et al., A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1. Genes Cells. 1999 Jan;4(1):67-75
J:57719 Miyamoto Y, et al., Circadian regulation of cryptochrome genes in the mouse. Brain Res Mol Brain Res. 1999 Aug 25;71(2):238-43
J:62186 Hida A, et al., The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription. Genomics. 2000 May 1;65(3):224-33
J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
J:73173 Vielhaber EL, et al., Nuclear Export of Mammalian PERIOD Proteins. J Biol Chem. 2001 Dec 7;276(49):45921-7
J:73655 Lee C, et al., Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28;107(7):855-67
J:87263 Kawamoto T, et al., A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004 Jan 2;313(1):117-24
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:91747 Takano A, et al., Identification of mPer1 phosphorylation sites responsible for the nuclear entry. J Biol Chem. 2004 Jul 30;279(31):32578-85
J:98340 Masubuchi S, et al., Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein. J Neurosci. 2005 May 11;25(19):4719-24
J:106987 Chaves I, et al., Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance. Mol Cell Biol. 2006 Mar;26(5):1743-53
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:150148 Etchegaray JP, et al., Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul;29(14):3853-66
J:174435 Schmutz I, et al., Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock. PLoS One. 2011;6(6):e21325
J:177139 Lee HM, et al., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16451-6
J:181980 Kucera N, et al., Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3311-6
J:189236 Kowalska E, et al., Distinct Roles of DBHS Family Members in the Circadian Transcriptional Feedback Loop. Mol Cell Biol. 2012 Nov;32(22):4585-94
J:205048 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704
J:209461 Han DH, et al., Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):170-80
J:209614 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. J Biol Chem. 2014 Apr 25;289(17):11791-806
J:215244 Preussner M, et al., Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice. Mol Cell. 2014 May 22;54(4):651-62
J:215857 Yang Y, et al., Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2. Biol Open. 2012 Aug 15;1(8):789-801
J:244091 Noh JY, et al., Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice. Exp Mol Med. 2014 Mar 07;46:e81
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320290 Vielhaber E, et al., Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol. 2000 Jul;20(13):4888-99