Sequence Detail

ID/Version

O35936 B1ASX5 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polyunsaturated fatty acid lipoxygenase ALOX8 {ECO:0000305};AltName: Full=15-lipoxygenase 2 {ECO:0000250|UniProtKB:O15296}; Short=15-LOX-2 {ECO:0000250|UniProtKB:O15296};AltName: Full=Arachidonate 15-lipoxygenase B; Short=15-

Provider

SWISS-PROT

Sequence

Polypeptide 677 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alox8	arachidonate 8-lipoxygenase	81	97	4	9

Sequence references in MGI

J:43206 Jisaka M, et al., Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. J Biol Chem. 1997 Sep 26;272(39):24410-6
J:46809 Krieg P, et al., cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim Biophys Acta. 1998 Mar 6;1391(1):7-12
J:96098 Kim E, et al., An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Oncogene. 2005 Feb 10;24(7):1174-87
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:133831 Muga SJ, et al., 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes. Cell Growth Differ. 2000 Aug;11(8):447-54
J:200515 Jisaka M, et al., Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J Biol Chem. 2000 Jan 14;275(2):1287-93
J:236930 Bender G, et al., Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS. J Biol Chem. 2016 Sep 9;291(37):19413-24
J:287056 Jisaka M, et al., Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist. Biochem Biophys Res Commun. 2005 Dec 9;338(1):136-43