Sequence Detail

ID/Version

O35906 O35909 O55199 O35907 (UniProt | EBI)

Last sequence update: 2005-06-21
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Transcription factor Spi-B;

Provider

SWISS-PROT

Sequence

Polypeptide 267 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spib	Spi-B transcription factor (Spi-1/PU.1 related)	14	100	2	8

Sequence references in MGI

J:45245 Su GH, et al., Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. EMBO J. 1997 Dec 1;16(23):7118-29
J:46100 Chen HM, et al., Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor. Gene. 1998 Jan 30;207(2):209-18
J:76489 Dahl R, et al., Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J. 2002 May 1;21(9):2220-30
J:81227 Kim N, et al., The transcription factor Spi-B is not required for somatic hypermutation. Mol Immunol. 2003 Jan;39(10):577-83
J:88257 Garrett-Sinha LA, et al., PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity. 1999 Apr;10(4):399-408
J:93128 Hu CJ, et al., PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct;15(4):545-55
J:100286 Garrett-Sinha LA, et al., PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood. 2001 May 1;97(9):2908-12
J:113820 Hallier M, et al., The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J Biol Chem. 1996 May 10;271(19):11177-81