Sequence Detail

ID/Version

O35885 Q9WUJ7 (UniProt | EBI)

Last sequence update: 2003-03-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Achaete-scute homolog 2; Short=ASH-2; Short=mASH-2; Short=mASH2;

Provider

SWISS-PROT

Sequence

Polypeptide 263 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ascl2	achaete-scute family bHLH transcription factor 2	69	176	3	14

Sequence references in MGI

J:20553 Guillemot F, et al., Essential role of Mash-2 in extraembryonic development. Nature. 1994 Sep 22;371(6495):333-6
J:23260 Guillemot F, et al., Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet. 1995 Mar;9(3):235-42
J:40602 Alders M, et al., The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts. Hum Mol Genet. 1997 Jun;6(6):859-67
J:48170 Rossant J, et al., Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation. Mech Dev. 1998 May;73(2):183-91
J:57828 Tanaka M, et al., Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev. 1999 Sep;87(1-2):129-42
J:63702 Paulsen M, et al., Sequence conservation and variability of imprinting in the beckwith-wiedemann syndrome gene cluster in human and mouse. Hum Mol Genet. 2000 Jul 22;9(12):1829-41
J:208784 Liu X, et al., Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014 Mar 27;507(7493):513-8
J:224020 Schuijers J, et al., Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell. 2015 Feb 5;16(2):158-70
J:335660 Scott IC, et al., The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol. 2000 Jan;20(2):530-41