Sequence Detail

ID/Version

O35732 O35707 O35733 D3Z0W6 (UniProt | EBI)

Last sequence update: 2017-10-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=CASP8 and FADD-like apoptosis regulator;AltName: Full=Caspase homolog; Short=CASH;AltName: Full=Caspase-eight-related protein; Short=Casper;AltName: Full=Caspase-like apoptosis regulatory protein; Short=CLARP;AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 481 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cflar	CASP8 and FADD-like apoptosis regulator	60	102	3	13

Sequence references in MGI

J:41473 Irmler M, et al., Inhibition of death receptor signals by cellular FLIP [see comments]. Nature. 1997 Jul 10;388(6638):190-5
J:42098 Goltsev YV, et al., CASH, a novel caspase homologue with death effector domains. J Biol Chem. 1997 Aug 8;272(32):19641-4
J:63049 Yeh WC, et al., Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity. 2000 Jun;12(6):633-42
J:279494 Tang Y, et al., K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431