Sequence Detail

ID/Version

O35717 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Suppressor of cytokine signaling 2 {ECO:0000305}; Short=SOCS-2 {ECO:0000303|PubMed:9202125};

Provider

SWISS-PROT

Sequence

Polypeptide 198 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Socs2	suppressor of cytokine signaling 2	43	101	3	30

Sequence references in MGI

J:43735 Starr R, et al., A family of cytokine-inducible inhibitors of signalling. Nature. 1997 Jun 26;387(6636):917-21
J:62883 Polizzotto MN, et al., Expression of 'suppressor of cytokine signalling' (SOCS) genes in the developing and adult mouse nervous system. J Comp Neurol. 2000 Jul 24;423(2):348-58
J:63006 Metcalf D, et al., Gigantism in mice lacking suppressor of cytokine signalling-2. Nature. 2000 Jun 29;405(6790):1069-73
J:76873 Greenhalgh CJ, et al., Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b). Mol Endocrinol. 2002 Jun;16(6):1394-406
J:95918 Greenhalgh CJ, et al., SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest. 2005 Feb;115(2):397-406
J:280563 Lear TB, et al., KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 Oct 3;4(19)