Sequence Detail

ID/Version

O35716 Q3U3L0 O35960 A2RT46 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Suppressor of cytokine signaling 1 {ECO:0000305}; Short=SOCS-1 {ECO:0000305};AltName: Full=JAK-binding protein; Short=JAB;AltName: Full=STAT-induced STAT inhibitor 1 {ECO:0000303|PubMed:9202125}; Short=SSI-1 {ECO:0000

Provider

SWISS-PROT

Sequence

Polypeptide 212 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Socs1	suppressor of cytokine signaling 1	46	99	4	14

Sequence references in MGI

J:43733 Endo TA, et al., A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 1997 Jun 26;387(6636):921-4
J:43734 Naka T, et al., Structure and function of a new STAT-induced STAT inhibitor. Nature. 1997 Jun 26;387(6636):924-9
J:43735 Starr R, et al., A family of cytokine-inducible inhibitors of signalling. Nature. 1997 Jun 26;387(6636):917-21
J:51281 Starr R, et al., Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14395-9
J:52380 Nicholson SE, et al., Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 1999 Jan 15;18(2):375-85
J:63471 Gregorieff A, et al., Regulation of SOCS-1 expression by translational repression. J Biol Chem. 2000 Jul 14;275(28):21596-604
J:79351 Toniato E, et al., TRIM8/GERP RING Finger Protein Interacts with SOCS-1. J Biol Chem. 2002 Oct 4;277(40):37315-22
J:91027 Ueki K, et al., Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol. 2004 Jun;24(12):5434-46
J:96151 Qing Y, et al., Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation. J Biol Chem. 2005 Jan 21;280(3):1849-53
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113957 Seki Y, et al., Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13003-8
J:159012 Hanada T, et al., A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box. J Biol Chem. 2001 Nov 2;276(44):40746-54
J:258710 Luckey MA, et al., The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat Immunol. 2014 Jul;15(7):638-45