Sequence Detail

ID/Version

O35704 Q8BH11 O54813 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine palmitoyltransferase 1; EC=2.3.1.50 {ECO:0000250|UniProtKB:O15269};AltName: Full=Long chain base biosynthesis protein 1; Short=LCB 1;AltName: Full=Serine-palmitoyl-CoA transferase 1; Short=SPT 1; Short=

Provider

SWISS-PROT

Sequence

Polypeptide 473 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sptlc1	serine palmitoyltransferase, long chain base subunit 1	30	101	3	15

Sequence references in MGI

J:43725 Weiss B, et al., Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem. 1997 Oct 1;249(1):239-47
J:44738 Hanada K, et al., A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J Biol Chem. 1997 Dec 19;272(51):32108-14
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:228796 Cantalupo A, et al., Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep;21(9):1028-37
J:240861 Alexaki A, et al., De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem. 2017 Mar 03;292(9):3929-3939
J:255961 Chaurasia B, et al., Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism. Cell Metab. 2016 Dec 13;24(6):820-834
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89