Sequence Detail

ID/Version

O35632 Q99MS9 Q99MT0 O35631 (UniProt | EBI)

Last sequence update: 2002-11-15
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Hyaluronidase-2; Short=Hyal-2; EC=3.2.1.35;AltName: Full=Hyaluronoglucosaminidase-2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 473 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hyal2	hyaluronoglucosaminidase 2	145	109	4	19

Sequence references in MGI

J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
J:146040 Jadin L, et al., Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?. FASEB J. 2008 Dec;22(12):4316-26
J:182416 Rai SK, et al., Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4443-8
J:193882 Chowdhury B, et al., Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction. J Biol Chem. 2013 Jan 4;288(1):520-8
J:238703 Muggenthaler MM, et al., Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. PLoS Genet. 2017 Jan;13(1):e1006470