Sequence Detail

ID/Version

O35625 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Axin-1;AltName: Full=Axis inhibition protein 1;AltName: Full=Protein Fused;

Provider

SWISS-PROT

Sequence

Polypeptide 863 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Axin1	axin 1	195	122	3	30

Sequence references in MGI

J:41619 Zeng L, et al., The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell. 1997 Jul 11;90(1):181-92
J:94782 Rui Y, et al., Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 2004 Nov 24;23(23):4583-94
J:110693 Chen HJ, et al., The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
J:137475 Rui Y, et al., A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell. 2007 Aug;13(2):268-82
J:141207 Kim MJ, et al., SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J. 2008 Nov;22(11):3785-94
J:148434 Chen T, et al., Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J Biol Chem. 2009 Mar 13;284(11):6683-9
J:162068 Jho E, et al., A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem Biophys Res Commun. 1999 Dec 9;266(1):28-35
J:162153 Mao J, et al., Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell. 2001 Apr;7(4):801-9
J:201942 Jiang Y, et al., Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene. 2009 Aug 20;28(33):2999-3007
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89