Sequence Detail

ID/Version

O35613 Q9QWT8 Q9QWV3 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Death domain-associated protein 6;AltName: Full=Daxx;

Provider

SWISS-PROT

Sequence

Polypeptide 739 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Daxx	Fas death domain-associated protein	122	101	3	25

Sequence references in MGI

J:41242 Yang X, et al., Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76
J:65176 Rochat-Steiner V, et al., FIST/HIPK3. A Fas/fadd-interacting serine/threonine kinase that induces fadd phosphorylation and inhibits fas-mediated jun nh(2)-terminal kinase activation. J Exp Med. 2000 Oct 16;192(8):1165-74
J:81640 Ecsedy JA, et al., Homeodomain-interacting protein kinase 1 modulates daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol. 2003 Feb;23(3):950-60
J:114021 Emelyanov AV, et al., The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. J Biol Chem. 2002 Mar 29;277(13):11156-64
J:161214 Drane P, et al., The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010 Jun 15;24(12):1253-65
J:169813 Zhong S, et al., Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med. 2000 Feb 21;191(4):631-40
J:188393 Michod D, et al., Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron. 2012 Apr 12;74(1):122-35
J:209481 Lewis PW, et al., Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14075-80
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89