Sequence Detail

ID/Version

O35601 Q9Z2H3 (UniProt | EBI)

Last sequence update: 2000-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=FYN-binding protein 1;AltName: Full=Adhesion and degranulation promoting adaptor protein; Short=ADAP;AltName: Full=FYB-120/130; Short=p120/p130;AltName: Full=FYN-T-binding protein;AltName: Full=SLAP-130;AltName: Full=SLP-76-a

Provider

SWISS-PROT

Sequence

Polypeptide 819 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fyb1	FYN binding protein 1	22	97	3	9

Sequence references in MGI

J:41750 da Silva AJ, et al., Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8
J:57919 Veale M, et al., Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production. J Biol Chem. 1999 Oct 1;274(40):28427-35
J:82731 Fujii Y, et al., Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 2003 Apr 10;540(1-3):111-6
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:144396 Kasirer-Friede A, et al., ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2007 Feb 1;109(3):1018-25
J:178334 Azhibekov TA, et al., TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation. Am J Physiol Cell Physiol. 2011 Dec;301(6):C1351-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89