Sequence Detail

ID/Version

O35598 B8JJJ0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Disintegrin and metalloproteinase domain-containing protein 10; Short=ADAM 10; EC=3.4.24.81 {ECO:0000269|PubMed:17245433, ECO:0000269|PubMed:29325091, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30639848};AltName: Full=Ku

Provider

SWISS-PROT

Sequence

Polypeptide 749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adam10	a disintegrin and metallopeptidase domain 10	159	112	4	17

Sequence references in MGI

J:49074 Pan D, et al., Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell. 1997 Jul 25;90(2):271-80
J:64122 Hattori M, et al., Regulated cleavage of a contact-mediated axon repellent [see comments] [comment]. Science. 2000 Aug 25;289(5483):1360-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:201438 Marcello E, et al., Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest. 2013 Jun 3;123(6):2523-38
J:209476 Haining EJ, et al., The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J Biol Chem. 2012 Nov 16;287(47):39753-65
J:273527 Li N, et al., Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 2007 Jan 24;26(2):494-504
J:276403 Wang X, et al., alpha-secretase ADAM10 physically interacts with beta-secretase BACE1 in neurons and regulates CHL1 proteolysis. J Mol Cell Biol. 2018 Oct 1;10(5):411-422
J:276414 Defourny J, et al., EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions. iScience. 2019 Jan 25;11:246-257
J:276415 Shah J, et al., A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity. Cell Rep. 2018 Nov 20;25(8):2132-2147.e7
J:276422 Farber G, et al., Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Angiogenesis. 2018 May;21(2):335-347
J:276496 Farber G, et al., ADAM10 controls the differentiation of the coronary arterial endothelium. Angiogenesis. 2019 May;22(2):237-250
J:283178 Brummer T, et al., The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation. FASEB J. 2018 Jul;32(7):3560-3573
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89