Sequence Detail

ID/Version

O35526 (UniProt | EBI)

Last sequence update: 2001-12-19
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Syntaxin-1A;AltName: Full=Neuron-specific antigen HPC-1;

Provider

SWISS-PROT

Sequence

Polypeptide 288 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stx1a	syntaxin 1A (brain)	164	135	3	25

Sequence references in MGI

J:99919 Hutt DM, et al., Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. J Biol Chem. 2005 May 27;280(21):20197-203
J:116097 Roux I, et al., Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell. 2006 Oct 20;127(2):277-89
J:134722 Ohara-Imaizumi M, et al., Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis. J Cell Biol. 2007 May 21;177(4):695-705
J:136786 Ihara M, et al., Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007 Feb 15;53(4):519-33
J:141196 Park WJ, et al., Leucine-rich glioma inactivated 3 associates with syntaxin 1. Neurosci Lett. 2008 Oct 31;444(3):240-4
J:178002 Bhatnagar S, et al., Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet. 2011 Oct;7(10):e1002323
J:240705 Liang T, et al., New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment. J Biol Chem. 2017 Feb 10;292(6):2203-2216
J:245492 Wheeler SE, et al., The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1. Diabetes. 2017 Sep;66(9):2327-2338
J:249825 Park S, et al., UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. J Neurosci. 2017 Sep 6;37(36):8797-8815
J:255335 Tan GH, et al., PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2018 Jan;28(1):90-110
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:266473 Ito H, et al., Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. J Neurochem. 2009 Feb;108(4):867-80
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89