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Sequence Detail
ID/Version
O35516 Q06008 Q60941 (UniProt | EBI) Last sequence update: 1998-01-01
Last annotation update: 2014-10-01
Sequence
description
from provider
RecName: Full=Neurogenic locus notch homolog protein 2; Short=Notch 2;AltName: Full=Motch B;Contains: RecName: Full=Notch 2 extracellular truncation;Contains: RecName: Full=Notch 2 intracellular domain;Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 2470 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Notch2 notch 2 57 36 5 33
Sequence references in MGI J:3995 Lardelli M, et al., Motch A and motch B--two mouse Notch homologues coexpressed in a wide variety of tissues. Exp Cell Res. 1993 Feb;204(2):364-72
J:23884 Higuchi M, et al., Differential expression of Notch1 and Notch2 in developing and adult mouse brain. Brain Res Mol Brain Res. 1995 Apr;29(2):263-72
J:36565 Milner LA, et al., Inhibition of granulocytic differentiation by mNotch1. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13014-9
J:55841 Hamada Y, et al., Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development. 1999 Aug;126(15):3415-24
J:88983 Wu L, et al., Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. Gene. 2004 Mar 17;328:153-65
J:140561 Fukushima H, et al., The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol. 2008 Oct;28(20):6402-12
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:177336 Takeuchi H, et al., Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16600-5
J:183220 Coleman ML, et al., Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007 Aug 17;282(33):24027-38
J:183961 Zheng X, et al., Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory