Sequence Detail

ID/Version

O35453 B2RSC4 Q9CW97 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine protease hepsin; EC=3.4.21.106 {ECO:0000305|PubMed:26673890, ECO:0000305|PubMed:9395459};Contains: RecName: Full=Serine protease hepsin non-catalytic chain;Contains: RecName: Full=Serine protease hepsin catalytic chain;

Provider

SWISS-PROT

Sequence

Polypeptide 436 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hpn	hepsin	65	117	3	7

Sequence references in MGI

J:44629 Vu TKH, et al., Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos. J Biol Chem. 1997 Dec 12;272(50):31315-20
J:45393 Wu Q, et al., Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. J Clin Invest. 1998 Jan 15;101(2):321-6
J:55901 Kawamura S, et al., Complete nucleotide sequence, origin of isoform and functional characterization of the mouse hepsin gene. Eur J Biochem. 1999 Jun;262(3):755-64
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:123922 Guipponi M, et al., Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss. Am J Pathol. 2007 Aug;171(2):608-16
J:243799 Brunati M, et al., The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. Elife. 2015 Dec 17;4:e08887
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:309157 Yu IS, et al., Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability. Thromb Haemost. 2000 Nov;84(5):865-70