Sequence Detail

ID/Version

O35425 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bcl-2-related ovarian killer protein {ECO:0000250|UniProtKB:Q9UMX3};AltName: Full=Apoptosis activator Mtd;AltName: Full=Protein matador;

Provider

SWISS-PROT

Sequence

Polypeptide 213 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bok	BCL2-related ovarian killer	109	103	4	15

Sequence references in MGI

J:61844 Inohara N, et al., Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. J Biol Chem. 1998 Apr 10;273(15):8705-10
J:203544 Schulman JJ, et al., The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. J Biol Chem. 2013 Aug 30;288(35):25340-9
J:223399 Carpio MA, et al., BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7201-6
J:228257 Echeverry N, et al., Intracellular localization of the BCL-2 family member BOK and functional implications. Cell Death Differ. 2013 Jun;20(6):785-99
J:234802 Schulman JJ, et al., The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors. J Biol Chem. 2016 May 27;291(22):11820-8
J:235305 D'Orsi B, et al., Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J Neurosci. 2016 Apr 20;36(16):4564-78
J:235310 Llambi F, et al., BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell. 2016 Apr 7;165(2):421-33
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89