Sequence Detail

ID/Version

O35405 Q3U5M5 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=5'-3' exonuclease PLD3; EC=3.1.16.1 {ECO:0000269|PubMed:30111894};AltName: Full=(S,S)-bis(monoacylglycero)phosphate synthase PLD3 {ECO:0000305|PubMed:39423811}; EC=3.1.4.- {ECO:0000269|PubMed:39423811};AltName: Full=Phospholi

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pld3	phospholipase D family member 3	46	103	3	88

Sequence references in MGI

J:51502 Pedersen KM, et al., Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain. J Biol Chem. 1998 Nov 20;273(47):31494-504
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:256592 Fazzari P, et al., PLD3 gene and processing of APP. Nature. 2017 Jan 25;541(7638):E1-E2
J:272267 Gonzalez AC, et al., Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes. Cell Rep. 2018 Jan 23;22(4):1040-1053
J:281205 Gavin AL, et al., PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nat Immunol. 2018 Sep;19(9):942-953
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292579 Gonzalez AC, PLD3 and spinocerebellar ataxia. Brain. 2018;141(11):e78
J:348522 Gavin AL, et al., Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors. Nat Commun. 2021 Oct 7;12(1):5874
J:358065 Singh S, et al., PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. Cell. 2024 Oct 15;