Sequence Detail

ID/Version

O35324 Q8C268 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=SH2 domain-containing protein 1B;AltName: Full=EWS/FLI1-activated transcript 2; Short=EAT-2;

Provider

SWISS-PROT

Sequence

Polypeptide 132 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sh2d1b1	SH2 domain containing 1B1	34	96	3	16

Sequence references in MGI

J:51754 Thompson AD, et al., EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene. 1996 Dec 19;13(12):2649-58
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106459 Calpe S, et al., Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics. 2006 Feb;58(1):15-25
J:110195 Roncagalli R, et al., Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005 Oct;6(10):1002-10
J:145969 Cruz-Munoz ME, et al., Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 2009 Mar;10(3):297-305
J:166054 Wang N, et al., Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol. 2010 Nov 15;185(10):5683-7
J:212410 Perez-Quintero LA, et al., EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cgamma, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014 Apr 7;211(4):727-42
J:243528 Talaei N, et al., Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling. J Immunol. 2015 Nov 15;195(10):4623-31