Sequence Detail

ID/Version

O35253 O88709 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=SMAD family member 7 {ECO:0000312|MGI:MGI:1100518}; Short=SMAD 7 {ECO:0000305};AltName: Full=Mothers against decapentaplegic homolog 7; Short=MAD homolog 7; Short=Mothers against DPP homolog 7;AltName: Full=Mothers ag

Provider

SWISS-PROT

Sequence

Polypeptide 426 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smad7	SMAD family member 7	112	119	3	82

Sequence references in MGI

J:43278 Nakao A, et al., Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling [see comments]. Nature. 1997 Oct 9;389(6651):631-5
J:87112 Koinuma D, et al., Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO J. 2003 Dec 15;22(24):6458-6470
J:198828 Kelly CE, et al., Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 2013;11(4):e1001538
J:384293 Pulaski L, et al., Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation. J Biol Chem. 2001 Apr 27;276(17):14344-9
J:384435 Kuratomi G, et al., NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J. 2005 Mar 15;386(Pt 3):461-70