Sequence Detail

ID/Version

O35245 C0KJK2 Q8BPR6 E9Q4F6 Q9ES37 Q9QWP0 Q9Z194 Q9Z193 E9QQA3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polycystin-2;AltName: Full=Polycystic kidney disease 2 protein homolog;AltName: Full=Transient receptor potential cation channel subfamily P member 2 {ECO:0000312|MGI:MGI:1099818};

Provider

SWISS-PROT

Sequence

Polypeptide 966 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pkd2	polycystin 2, transient receptor potential cation channel	256	127	3	37

Sequence references in MGI

J:41134 Wu G, et al., Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2. Genomics. 1997 Oct 1;45(1):220-3
J:47035 Wu G, et al., Somatic inactivation of Pkd2 results in polycystic kidney disease. Cell. 1998 Apr 17;93(2):177-88
J:49651 Pennekamp P, et al., Characterization of the murine polycystic kidney disease (Pkd2) gene. Mamm Genome. 1998 Sep;9(9):749-52
J:59314 Wu G, et al., Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet. 2000 Jan;24(1):75-8
J:63279 Park JH, et al., Cloning and characterization of the murine pkd2 promoter. Genomics. 2000 Jun 15;66(3):305-12
J:65183 Lehtonen S, et al., In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. J Biol Chem. 2000 Oct 20;275(42):32888-93
J:77401 Pennekamp P, et al., The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol. 2002 Jun 4;12(11):938-43
J:81443 Nauli SM, et al., Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb;33(2):129-37
J:82514 Luo Y, et al., Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol. 2003 Apr;23(7):2600-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104127 Hackmann K, et al., A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1. Hum Mol Genet. 2005 Nov 1;14(21):3249-62
J:120848 Anyatonwu GI, et al., Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6454-9
J:149929 Sohara E, et al., Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol. 2008 Mar;19(3):469-76
J:169812 Foggensteiner L, et al., Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J Am Soc Nephrol. 2000 May;11(5):814-27
J:170490 Field S, et al., Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development. 2011 Mar;138(6):1131-42
J:173554 Choi YH, et al., Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84
J:175122 Gallagher AR, et al., The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4017-22
J:187958 Yoshiba S, et al., Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science. 2012 Oct 12;338(6104):226-31
J:236814 Kim S, et al., The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 Jul;18(7):752-64
J:240321 Kleene SJ, et al., The native TRPP2-dependent channel of murine renal primary cilia. Am J Physiol Renal Physiol. 2017 Jan 01;312(1):F96-F108
J:269113 Bulley S, et al., Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. Elife. 2018 Dec 4;7:e42628
J:274079 Kim H, et al., Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun. 2014 Nov 18;5:5482
J:275590 Arhatte M, et al., TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nat Commun. 2019 May 2;10(1):2024
J:285899 Hasan R, et al., SUMO1 modification of PKD2 channels regulates arterial contractility. Proc Natl Acad Sci U S A. 2019 Dec 10;
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:310479 Liu X, et al., Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 2018 Feb 14;7:e33183
J:336740 Katoh TA, et al., Immotile cilia mechanically sense the direction of fluid flow for left-right determination. Science. 2023 Jan 6;379(6627):66-71