Sequence Detail

ID/Version

O35160 Q0VB03 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Pituitary homeobox 3;AltName: Full=Homeobox protein PITX3;AltName: Full=Paired-like homeodomain transcription factor 3;

Provider

SWISS-PROT

Sequence

Polypeptide 302 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pitx3	paired-like homeodomain transcription factor 3	53	134	3	14

Sequence references in MGI

J:43830 Semina EV, et al., Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19. Hum Mol Genet. 1997 Nov;6(12):2109-16
J:47921 Semina EV, et al., A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Nat Genet. 1998 Jun;19(2):167-70
J:99395 Maxwell SL, et al., Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Dev Biol. 2005 Jun 15;282(2):467-79
J:144189 Jacobs FM, et al., Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009 Feb;136(4):531-40
J:144758 Ho HY, et al., Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. Mech Dev. 2009 Jan-Feb;126(1-2):18-29
J:151273 Medina-Martinez O, et al., Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009 Mar 30;238(9):2193-2201
J:168199 Messmer K, et al., Induction of tyrosine hydroxylase expression by the transcription factor Pitx3. Int J Dev Neurosci. 2007 Feb;25(1):29-37