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Sequence Detail
ID/Version
O09161 O88505 Q56A03 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2019-07-31
Sequence
description
from provider
RecName: Full=Calsequestrin-2;AltName: Full=Calsequestrin, cardiac muscle isoform;Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 415 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Casq2 calsequestrin 2 37 14 8 14
Sequence references in MGI J:50093 Park KW, et al., Cloning of the genes encoding mouse cardiac and skeletal calsequestrins: expression pattern during embryogenesis. Gene. 1998 Sep 14;217(1-2):25-30
J:114621 Knollmann BC, et al., Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2006 Sep;116(9):2510-20
J:124211 Song L, et al., Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2007 Jul;117(7):1814-23
J:159954 Kalyanasundaram A, et al., The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering. J Biol Chem. 2010 Jan 29;285(5):3076-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory