Sequence Detail

ID/Version

O09127 A3KG07 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ephrin type-A receptor 8; EC=2.7.10.1;AltName: Full=EPH- and ELK-related kinase;AltName: Full=Tyrosine-protein kinase receptor EEK;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1004 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Epha8	Eph receptor A8	53	118	3	8

Sequence references in MGI

J:38350 Park S, et al., The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
J:41127 Park S, et al., Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. EMBO J. 1997 Jun 2;16(11):3106-14
J:129044 Shin J, et al., Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol Cell Biol. 2007 Dec;27(23):8113-26
J:161729 Kim J, et al., The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors. Mol Cell Biol. 2010 Apr;30(7):1582-92
J:177162 Gu C, et al., The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells. Oncogene. 2005 Jun 16;24(26):4243-56
J:177172 Gu C, et al., The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol Cell Biol. 2001 Jul;21(14):4579-97
J:177175 Choi S, et al., Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. Oncogene. 1999 Sep 23;18(39):5413-22