Sequence Detail

ID/Version

O09106 P97476 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone deacetylase 1 {ECO:0000303|PubMed:9271381}; Short=HD1 {ECO:0000303|PubMed:9271381}; EC=3.5.1.98 {ECO:0000269|PubMed:10615135, ECO:0000269|PubMed:21960634, ECO:0000305|PubMed:30279482};AltName: Full=Protein deacetylase

Provider

SWISS-PROT

Sequence

Polypeptide 482 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hdac1	histone deacetylase 1	236	139	4	34

Sequence references in MGI

J:42359 Bartl S, et al., Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Mol Cell Biol. 1997 Sep;17(9):5033-43
J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
J:67665 Zhang CL, et al., Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001 Jan 5;276(1):35-9
J:82069 Yang L, et al., An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J. 2003 Feb 1;369(Pt 3):651-7
J:84768 Alland L, et al., Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol Cell Biol. 2002 Apr;22(8):2743-50
J:87046 Zoltewicz JS, et al., Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development. 2004 Jan;131(1):3-14
J:97578 Mejat A, et al., Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression. Nat Neurosci. 2005 Mar;8(3):313-21
J:100129 Zhou Y, et al., The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol. 2005 Aug 9;15(15):1434-8
J:106935 Davis CA, et al., PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006 Apr;26(7):2626-36
J:113866 Fuks F, et al., DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet. 2000 Jan;24(1):88-91
J:114014 Vaute O, et al., Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res. 2002 Jan 15;30(2):475-81
J:114106 Kurtev V, et al., Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004 Jun 4;279(23):24834-43
J:132209 Mehra-Chaudhary R, et al., Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. Biochem J. 2001 Jan 1;353(Pt 1):13-22
J:144189 Jacobs FM, et al., Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009 Feb;136(4):531-40
J:144592 Choi E, et al., A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. J Biol Chem. 2008 Dec 12;283(50):35283-94
J:150360 Nimura K, et al., A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature. 2009 Jul 9;460(7252):287-91
J:150656 Yang Z, et al., Znhit1 causes cell cycle arrest and down-regulates CDK6 expression. Biochem Biophys Res Commun. 2009 Aug 14;386(1):146-52
J:150926 Zhou Y, et al., The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J. 2002 Sep 2;21(17):4632-40
J:160788 Li Z, et al., An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene. 2010 May 6;29(18):2659-71
J:165945 Bruscoli S, et al., Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. J Biol Chem. 2010 Apr 2;285(14):10385-96
J:166802 Yan W, et al., Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem. 2010 Oct 8;285(41):31418-26
J:169899 Brown MA, et al., Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer. 2006;5:26
J:170037 Brandt S, et al., SLy2 targets the nuclear SAP30/HDAC1 complex. Int J Biochem Cell Biol. 2010 Sep;42(9):1472-81
J:175166 Saleque S, et al., Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007 Aug 17;27(4):562-72
J:176119 DiTacchio L, et al., Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011 Sep 30;333(6051):1881-5
J:190264 Alter J, et al., Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation. PLoS One. 2011;6(12):e29498
J:203400 He Z, et al., A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J Biol Chem. 2011 Mar 4;286(9):7279-89
J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
J:209491 Naruse Y, et al., Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol Cell Biol. 2004 Jul;24(14):6278-87
J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32
J:227377 Lu P, et al., The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. J Biol Chem. 2011 May 20;286(20):18311-9
J:240892 Nitarska J, et al., A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 Nov 01;17(6):1683-1698
J:243422 Streubel G, et al., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017 Aug 01;36(15):2216-2232
J:307864 Horisawa-Takada Y, et al., Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nat Commun. 2021 Jun 1;12(1):3184
J:319689 Zhang T, et al., A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes. Nat Commun. 2018 Sep 18;9(1):3798
J:319940 Yan L, et al., PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021 Aug;8(16):e2102060
J:319948 Kelly RDW, et al., Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Sci Rep. 2018 Oct 2;8(1):14690
J:322384 Zheng S, et al., The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination. J Biol Chem. 2021 Apr 5;:100625
J:338159 Li Y, et al., The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. J Genet Genomics. 2022 Nov;49(11):1029-1041