Sequence Detail

ID/Version

O09053 O09050 Q80YP9 Q9JKD4 Q9Z242 Q9Z241 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN {ECO:0000305};AltName: Full=Werner syndrome protein homolog {ECO:0000305};Includes: RecName: Full=3'-5' exonuclease; EC=3.1.-.- {ECO:0000269|PubMed:17229737};Includes: Rec

Provider

SWISS-PROT

Sequence

Polypeptide 1401 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wrn	Werner syndrome RecQ like helicase	148	99	3	12

Sequence references in MGI

J:39875 Imamura O, et al., Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization. Genomics. 1997 Apr 15;41(2):298-300
J:61567 Lombard DB, et al., Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol. 2000 May;20(9):3286-91
J:69903 Kawabe Yi, et al., A novel protein interacts with the Werner's syndrome gene product physically and functionally. J Biol Chem. 2001 Jun 8;276(23):20364-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89