Sequence Detail

ID/Version

O08966 Q9R1Q4 (UniProt | EBI)

Last sequence update: 2008-05-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Solute carrier family 22 member 1 {ECO:0000303|PubMed:12176030};AltName: Full=Organic cation transporter 1 {ECO:0000303|PubMed:12176030}; Short=mOCT1 {ECO:0000303|PubMed:12176030};

Provider

SWISS-PROT

Sequence

Polypeptide 556 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc22a1	solute carrier family 22 (organic cation transporter), member 1	171	107	3	10

Sequence references in MGI

J:35906 Schweifer N, et al., The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome. 1996 Oct;7(10):735-40
J:55220 Green RM, et al., Cloning and functional expression of a mouse liver organic cation transporter. Hepatology. 1999 May;29(5):1556-62
J:70604 Jonker JW, et al., Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol. 2001 Aug;21(16):5471-7
J:78891 Kakehi M, et al., Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50
J:212164 Chen L, et al., OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8
J:258547 Kim HI, et al., Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017 Oct 5;101(4):489-502
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331353 Sala-Rabanal M, et al., Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Mol Pharm. 2013 Apr 1;10(4):1450-8
J:331354 Han TK, et al., Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Mol Pharmacol. 2013 Aug;84(2):182-9
J:331913 Jensen O, et al., Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport. Front Pharmacol. 2021;12:674559
J:331920 Meyer MJ, et al., Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1. J Biol Chem. 2022 Apr 22;298(6):101974