Sequence Detail

ID/Version

O08901 O09007 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitotic checkpoint serine/threonine-protein kinase BUB1; Short=mBUB1; EC=2.7.11.1;AltName: Full=BUB1A;

Provider

SWISS-PROT

Sequence

Polypeptide 1058 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bub1	BUB1, mitotic checkpoint serine/threonine kinase	49	109	3	29

Sequence references in MGI

J:40780 Taylor SS, et al., Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 1997 May 30;89(5):727-35
J:45566 Pangilinan F, et al., Mammalian BUB1 protein kinases: map positions and in vivo expression. Genomics. 1997 Dec 15;46(3):379-88
J:128455 Perera D, et al., Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell. 2007 Oct;13(4):566-79
J:135093 Jeganathan K, et al., Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007 Oct 22;179(2):255-67
J:159053 Tilston V, et al., Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation. BMC Res Notes. 2009;2:190
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89