Sequence Detail

ID/Version

O08852 E9QJR6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Polycystin-1 {ECO:0000305};AltName: Full=Autosomal dominant polycystic kidney disease 1 protein homolog;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 4293 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pkd1	polycystin 1, transient receptor potential channel interacting	144	142	4	54

Sequence references in MGI

J:39623 Lohning C, et al., The mouse homolog of PKD1: sequence analysis and alternative splicing. Mamm Genome. 1997 May;8(5):307-11
J:81443 Nauli SM, et al., Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb;33(2):129-37
J:96951 Murakami M, et al., Genomic organization and functional analysis of murine PKD2L1. J Biol Chem. 2005 Feb 18;280(7):5626-35
J:127628 Yu S, et al., Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93
J:165121 Wodarczyk C, et al., Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals. PLoS One. 2010;5(9):e12719
J:214729 Su X, et al., Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum Mol Genet. 2014 Oct 15;23(20):5441-51
J:236814 Kim S, et al., The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 Jul;18(7):752-64
J:274079 Kim H, et al., Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun. 2014 Nov 18;5:5482