Sequence Detail

ID/Version

O08808 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein diaphanous homolog 1;AltName: Full=Diaphanous-related formin-1; Short=DRF1;AltName: Full=p140mDIA; Short=mDIA1 {ECO:0000303|PubMed:23558171};

Provider

SWISS-PROT

Sequence

Polypeptide 1255 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Diaph1	diaphanous related formin 1	67	118	2	98

Sequence references in MGI

J:41124 Watanabe N, et al., p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 1997 Jun 2;16(11):3044-56
J:62164 Fujiwara T, et al., Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000 May 19;271(3):626-9
J:88572 Shimada A, et al., The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol Cell. 2004 Feb 27;13(4):511-22
J:139152 Schwaibold EM, et al., Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1. Biochem Biophys Res Commun. 2008 Aug 29;373(3):366-72
J:150313 Brandt DT, et al., SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009 May;11(5):557-68
J:228552 Ercan-Sencicek AG, et al., Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans. Eur J Hum Genet. 2015 Feb;23(2):165-72
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:265603 Baarlink C, et al., Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science. 2013 May 17;340(6134):864-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89