Sequence Detail

ID/Version

O08788 Q3TZG7 E9QLJ1 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Dynactin subunit 1;AltName: Full=150 kDa dynein-associated polypeptide;AltName: Full=DAP-150; Short=DP-150;AltName: Full=p150-glued;

Provider

SWISS-PROT

Sequence

Polypeptide 1281 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dctn1	dynactin 1	144	99	4	22

Sequence references in MGI

J:38477 Jang W, et al., Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a candidate for the neuromuscular disease mutation mnd2. Biochem Biophys Res Commun. 1997 Feb 13;231(2):344-7
J:86328 Liu JJ, et al., BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol. 2003 Oct 27;163(2):223-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112743 Peris L, et al., Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. J Cell Biol. 2006 Sep 11;174(6):839-49
J:197308 Ohbayashi N, et al., Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012 Mar 15;125(Pt 6):1508-18
J:200276 Splinter D, et al., BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012 Nov;23(21):4226-41
J:207807 Kodani A, et al., Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013 Feb 20;32(4):597-607
J:236210 Li K, et al., HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes. J Cell Sci. 2014 Nov 1;127(Pt 21):4574-88
J:245166 Chanduri M, et al., Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. Biochem J. 2016 Oct 01;473(19):3031-47
J:273640 Camargo Ortega G, et al., The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature. 2019 Mar;567(7746):113-117
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89