Sequence Detail

ID/Version

O08785 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Circadian locomoter output cycles protein kaput; Short=mCLOCK; EC=2.3.1.48;

Provider

SWISS-PROT

Sequence

Polypeptide 855 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clock	clock circadian regulator	153	131	4	64

Sequence references in MGI

J:40363 Antoch MP, et al., Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell. 1997 May 16;89(4):655-67
J:40364 King DP, et al., Positional cloning of the mouse circadian clock gene. Cell. 1997 May 16;89(4):641-53
J:48067 Gekakis N, et al., Role of the CLOCK protein in the mammalian circadian mechanism [see comments]. Science. 1998 Jun 5;280(5369):1564-9
J:66232 Wilsbacher LD, et al., The mouse clock locus: sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Res. 2000 Dec;10(12):1928-40
J:73655 Lee C, et al., Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28;107(7):855-67
J:84699 Kondratov RV, et al., BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 2003 Aug 1;17(15):1921-32
J:87263 Kawamoto T, et al., A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004 Jan 2;313(1):117-24
J:112955 Kwon I, et al., BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol Cell Biol. 2006 Oct;26(19):7318-30
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:121658 DeBruyne JP, et al., CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May;10(5):543-5
J:130591 Hirayama J, et al., CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature. 2007 Dec 13;450(7172):1086-90
J:135812 Bertolucci C, et al., Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol. 2008 May;28(9):3070-5
J:139295 Nakahata Y, et al., The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008 Jul 25;134(2):329-40
J:139296 Asher G, et al., SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25;134(2):317-28
J:143808 Langmesser S, et al., Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol. 2008;9:41
J:147991 Ramsey KM, et al., Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009 May 1;324(5927):651-4
J:147996 Nakahata Y, et al., Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science. 2009 May 1;324(5927):654-7
J:148217 Nader N, et al., Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 2009 May;23(5):1572-83
J:150025 Yoshitane H, et al., Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Mol Cell Biol. 2009 Jul;29(13):3675-86
J:154880 Sasaki M, et al., Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem. 2009 Sep 11;284(37):25149-59
J:162577 Guillaumond F, et al., Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver. Mol Cell Biol. 2010 Jun;30(12):3059-70
J:162641 Marcheva B, et al., Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 Jul 29;466(7306):627-31
J:165365 Doi R, et al., CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J Biol Chem. 2010 Jul 16;285(29):22114-21
J:166235 Andrews JL, et al., CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19090-5
J:173042 Hara Y, et al., Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter. Nucleic Acids Res. 2009 Mar;37(4):1115-26
J:176119 DiTacchio L, et al., Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science. 2011 Sep 30;333(6051):1881-5
J:176743 Koyanagi S, et al., cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011 Sep 16;286(37):32416-23
J:177139 Lee HM, et al., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16451-6
J:188853 Huang N, et al., Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012 Jul 13;337(6091):189-94
J:189804 Spengler ML, et al., Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65
J:189932 Peruquetti RL, et al., Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012;7(8):e42695
J:198047 Li MD, et al., O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 2013 Feb 5;17(2):303-10
J:198048 Kaasik K, et al., Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5;17(2):291-302
J:198078 Oishi K, et al., The molecular clock regulates circadian transcription of tissue factor gene. Biochem Biophys Res Commun. 2013 Feb 8;431(2):332-5
J:199564 Baeza-Raja B, et al., p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19;33(25):10221-34
J:201135 Lande-Diner L, et al., A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16021-16026
J:204645 Zhao WN, et al., CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar;9(3):268-75
J:205048 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704
J:205584 Menet JS, et al., CLOCK:BMAL1 is a pioneer-like transcription factor. Genes Dev. 2014 Jan 1;28(1):8-13
J:205586 Annayev Y, et al., Gene model 129 (gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem. 2014 Feb 21;289(8):5013-24
J:206921 Schoenhard JA, et al., Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J Mol Cell Cardiol. 2003 May;35(5):473-81
J:207820 Curtis AM, et al., Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004 Feb 20;279(8):7091-7
J:207831 Musiek ES, et al., Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013 Dec 2;123(12):5389-400
J:209461 Han DH, et al., Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):170-80
J:211243 Ward SM, et al., The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010 Dec 10;285(50):38987-9000
J:211865 Gao Y, et al., Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells. Biochem Biophys Res Commun. 2014 Jan 10;443(2):586-91
J:213082 Li DQ, et al., Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun. 2013;4:2545
J:215875 Katada S, et al., The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat Struct Mol Biol. 2010 Dec;17(12):1414-21
J:215957 Stashi E, et al., SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27;6(4):633-45
J:244448 Somanath PR, et al., Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype. J Cell Physiol. 2011 Jan;226(1):132-40
J:244832 Zhou B, et al., CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology. 2014 Jun;59(6):2196-206
J:250437 Lin R, et al., CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 5;68(1):198-209.e6
J:266073 Toledo M, et al., Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4
J:271702 Nakashima A, et al., Dec1 and CLOCK Regulate Na(+)/K(+)-ATPase beta1 Subunit Expression and Blood Pressure. Hypertension. 2018 Sep;72(3):746-754
J:272534 Lu Y, et al., Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. Oncotarget. 2017 Aug 15;8(33):54913-54924