Sequence Detail

ID/Version

O08759 Q8CE29 P97482 E9QKT1 (UniProt | EBI)

Last sequence update: 2015-04-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ubiquitin-protein ligase E3A; EC=2.3.2.26 {ECO:0000269|PubMed:20211139, ECO:0000269|PubMed:30020076};AltName: Full=HECT-type ubiquitin transferase E3A;AltName: Full=Oncogenic protein-associated protein E6-AP;

Provider

SWISS-PROT

Sequence

Polypeptide 870 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ube3a	ubiquitin protein ligase E3A	70	111	3	56

Sequence references in MGI

J:39671 Sutcliffe JS, et al., The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region [letter]. Genome Res. 1997 Apr;7(4):368-77
J:41090 Hatakeyama S, et al., Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem. 1997 Jun 13;272(24):15085-92
J:50811 Jiang YH, et al., Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 1998 Oct;21(4):799-811
J:75622 Miura K, et al., Neurobehavioral and electroencephalographic abnormalities in ube3a maternal-deficient mice. Neurobiol Dis. 2002 Mar;9(2):149-59
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:167955 Greer PL, et al., The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010 Mar 5;140(5):704-16
J:215947 Gossan NC, et al., The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. Nucleic Acids Res. 2014;42(9):5765-75
J:277268 Sun J, et al., UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. Elife. 2018 Jul 18;7:e37993
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89