Sequence Detail

ID/Version

O08738 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Caspase-6 {ECO:0000303|PubMed:9038361}; Short=CASP-6 {ECO:0000303|PubMed:9038361}; EC=3.4.22.59 {ECO:0000269|PubMed:22555455, ECO:0000269|PubMed:25231987};AltName: Full=Apoptotic protease Mch-2 {ECO:0000303|PubMed:9038361};Co

Provider

SWISS-PROT

Sequence

Polypeptide 276 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp6	caspase 6	76	103	5	14

Sequence references in MGI

J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
J:65496 Zheng TS, et al., Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nat Med. 2000 Nov;6(11):1241-7
J:140947 Watanabe C, et al., Caspase 6 regulates B cell activation and differentiation into plasma cells. J Immunol. 2008 Nov 15;181(10):6810-9
J:204791 Robert G, et al., The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. Cell Death Differ. 2012 Nov;19(11):1769-78
J:225058 Cusack CL, et al., Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning. Nat Commun. 2013;4:1876
J:290292 Zheng M, et al., Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell. 2020 Apr 30;181(3):674-687.e13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306586 Suzuki J, et al., Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. J Biol Chem. 2014 Oct 31;289(44):30257-30267
J:319823 Watanabe C, et al., Regulation of B-lineage cells by caspase 6. Immunol Cell Biol. 2018 Nov;96(10):1072-1082