Sequence Detail

ID/Version

O08715 O08714 P97488 B1AR25 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=A-kinase anchor protein 1, mitochondrial;AltName: Full=Dual specificity A-kinase-anchoring protein 1; Short=D-AKAP-1;AltName: Full=Protein kinase A-anchoring protein 1; Short=PRKA1;AltName: Full=Spermatid A-kinase anchor prot

Provider

SWISS-PROT

Sequence

Polypeptide 857 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akap1	A kinase anchor protein 1	41	102	4	48

Sequence references in MGI

J:39210 Huang LJ, et al., Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem. 1997 Mar 21;272(12):8057-64
J:41087 Chen Q, et al., Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria. J Biol Chem. 1997 Jun 13;272(24):15247-57
J:225481 Scorziello A, et al., NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death. J Cell Sci. 2013 Dec 15;126(Pt 24):5566-77
J:289389 Qi B, et al., Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis. Diabetologia. 2020 May;63(5):1072-1087
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89