Sequence Detail

ID/Version

O08601 Q91X33 B2CXA7 Q3UJA0 (UniProt | EBI)

Last sequence update: 2010-01-19
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Microsomal triglyceride transfer protein large subunit;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 894 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mttp	microsomal triglyceride transfer protein	68	103	3	10

Sequence references in MGI

J:32784 Nakamuta M, et al., Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression and chromosomal localization. Genomics. 1996 Apr 15;33(2):313-6
J:61175 Leung GK, et al., A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem. 2000 Mar 17;275(11):7515-20
J:61562 Shelton JM, et al., Microsomal triglyceride transfer protein expression during mouse development. J Lipid Res. 2000 Apr;41(4):532-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124933 Mohler PJ, et al., Identification of a novel isoform of microsomal triglyceride transfer protein. J Biol Chem. 2007 Sep 14;282(37):26981-8
J:125365 Dougan SK, et al., MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007 Mar 19;204(3):533-45
J:137715 Kamagate A, et al., FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest. 2008 Jun;118(6):2347-64
J:138737 Iqbal J, et al., Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition. J Biol Chem. 2008 Jul 18;283(29):19967-80
J:216037 Wang F, et al., LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver. J Mol Endocrinol. 2014 Apr;52(2):133-43
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296129 Rava P, et al., Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein. J Lipid Res. 2005 Aug;46(8):1779-85
J:296130 Rava P, et al., Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins. J Biol Chem. 2006 Apr 21;281(16):11019-27
J:306883 Peng H, et al., PRAP1 is a novel lipid binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport. J Biol Chem. 2020 Nov 9;