Sequence Detail

ID/Version

O08581 Q99L99 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Potassium channel subfamily K member 1;AltName: Full=Inward rectifying potassium channel protein TWIK-1 {ECO:0000303|PubMed:9013852};

Provider

SWISS-PROT

Sequence

Polypeptide 336 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnk1	potassium channel, subfamily K, member 1	86	106	4	10

Sequence references in MGI

J:38116 Lesage F, et al., The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett. 1997 Jan 27;402(1):28-32
J:46935 Arrighi I, et al., Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene. FEBS Lett. 1998 Mar 27;425(2):310-6
J:95306 Decressac S, et al., ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep. 2004 Dec;5(12):1171-5
J:108847 Nicolas MT, et al., Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear. Hear Res. 2003 Jul;181(1-2):20-6
J:182652 Chatelain FC, et al., TWIK1, a unique background channel with variable ion selectivity. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5499-504
J:183158 Millar ID, et al., Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice. Pflugers Arch. 2006 Oct;453(1):107-16
J:183234 Nie X, et al., Expression and insights on function of potassium channel TWIK-1 in mouse kidney. Pflugers Arch. 2005 Dec;451(3):479-88
J:206720 Hwang EM, et al., A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Nat Commun. 2014 Feb 5;5:3227
J:244846 Wang W, et al., The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments. Front Cell Neurosci. 2013;7:246
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:354170 Yarishkin O, et al., TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus. Mol Brain. 2014 Nov 19;7:80