Sequence Detail

ID/Version

O08539 Q62434 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Myc box-dependent-interacting protein 1;AltName: Full=Amphiphysin II;AltName: Full=Amphiphysin-like protein;AltName: Full=Bridging integrator 1;AltName: Full=SH3 domain-containing protein 9;

Provider

SWISS-PROT

Sequence

Polypeptide 588 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bin1	bridging integrator 1	106	105	3	12

Sequence references in MGI

J:35155 Sakamuro D, et al., BIN1 is a novel MYC-interacting protein with features of a tumour suppressor [see comments]. Nat Genet. 1996 Sep;14(1):69-77
J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
J:41089 Leprince C, et al., A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. J Biol Chem. 1997 Jun 13;272(24):15101-5
J:78444 Lee E, et al., Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science. 2002 Aug 16;297(5584):1193-6
J:81675 Modregger J, et al., Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. J Biol Chem. 2003 Feb 7;278(6):4160-7
J:83477 Leprince C, et al., Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci. 2003 May 15;116(Pt 10):1937-48
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:237310 Miyagawa T, et al., BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production. Hum Mol Genet. 2016 Jul 15;25(14):2948-2958
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89