Sequence Detail

ID/Version

G5E829 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Plasma membrane calcium-transporting ATPase 1 {ECO:0000305}; EC=7.2.2.10 {ECO:0000305|PubMed:24805951};AltName: Full=Plasma membrane calcium ATPase isoform 1 {ECO:0000303|PubMed:12209837}; Short=PMCA1 {ECO:0000303|PubMed:1220

Provider

SWISS-PROT

Sequence

Polypeptide 1220 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	54	104	4	25

Sequence references in MGI

J:91844 Okunade GW, et al., Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem. 2004 Aug 6;279(32):33742-50
J:119880 Liu L, et al., Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice. Am J Physiol Cell Physiol. 2007 Jan;292(1):C423-31
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:194387 Kim HJ, et al., Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24;199(7):1145-58
J:198280 Liu C, et al., Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b). J Biol Chem. 2013 Apr 19;288(16):11407-15
J:225010 Kobayashi Y, et al., Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation. Hypertension. 2012 Apr;59(4):854-60
J:232942 Ryan ZC, et al., Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3. Biochem Biophys Res Commun. 2015 Nov 6;467(1):152-6
J:256009 Korthals M, et al., A complex of Neuroplastin and Plasma Membrane Ca(2+) ATPase controls T cell activation. Sci Rep. 2017 Aug 21;7(1):8358
J:271691 Fujiwara A, et al., Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice. J Hypertens. 2014 Jul;32(7):1415-23; discussion 1423
J:271705 Ehara Y, et al., Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice. Hypertens Res. 2018 Sep;41(9):699-707
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304586 Ono Y, et al., Expression of plasma membrane calcium ATPases confers Ca(2+)/H(+) exchange in rodent synaptic vesicles. Sci Rep. 2019 Mar 12;9(1):4289