Sequence Detail

ID/Version

E9Q9A9 Q8K4E5 Q8VI92 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=2'-5'-oligoadenylate synthase 2; Short=(2-5')oligo(A) synthase 2; Short=2-5A synthase 2; EC=2.7.7.84 {ECO:0000269|PubMed:15865429, ECO:0000269|PubMed:29117179};AltName: Full=2',5'-oligoadenylate synthetase-like 11 {EC

Provider

SWISS-PROT

Sequence

Polypeptide 742 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Oas2	2'-5' oligoadenylate synthetase 2	53	99	2	23

Sequence references in MGI

J:77001 Perelygin AA, et al., Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9322-7
J:98376 Sarkar SN, et al., Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity. Biochemistry. 2005 May 10;44(18):6837-43
J:175745 Kakuta S, et al., Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. J Interferon Cytokine Res. 2002 Sep;22(9):981-93
J:185034 Perelygin AA, et al., The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. J Mol Evol. 2006 Oct;63(4):562-76
J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7
J:248944 Oakes SR, et al., A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation. PLoS Genet. 2017 Nov;13(11):e1007072