Sequence Detail

ID/Version

E9Q5R7 Q3UEM3 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=NACHT, LRR and PYD domains-containing protein 12;AltName: Full=Monarch-1;AltName: Full=PYRIN-containing APAF1-like protein 7; Short=PYPAF7;

Provider

SWISS-PROT

Sequence

Polypeptide 1054 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrp12	NLR family, pyrin domain containing 12	45	96	48	25

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:164725 Arthur JC, et al., Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol. 2010 Oct 15;185(8):4515-9
J:268356 Normand S, et al., Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nat Commun. 2018 Dec 17;9(1):5338
J:272644 Truax AD, et al., The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6
J:293592 Chen ST, et al., NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7