Sequence Detail

ID/Version

E9Q5F9 Q6PCY9 Q8K0F3 Q69ZC0 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase SETD2 {ECO:0000305}; EC=2.1.1.359 {ECO:0000269|PubMed:18157086};AltName: Full=Lysine N-methyltransferase 3A {ECO:0000250|UniProtKB:Q9BYW2};AltName: Full=Protein-lysine N-methyltransferase SETD2 {ECO

Provider

SWISS-PROT

Sequence

Polypeptide 2537 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Setd2	SET domain containing 2	66	101	3	31

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:130872 Edmunds JW, et al., Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J. 2008 Jan 23;27(2):406-20
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157570 Hu M, et al., Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
J:236080 Park IY, et al., Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell. 2016 Aug 11;166(4):950-62
J:243534 Zhang Y, et al., H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm. Cell Rep. 2014 Sep 25;8(6):1989-2002
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89